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Bioinformatics Research Scientist Chromatin Structure

Company: St. Jude Children's Research Hospital
Location: Raleigh
Posted on: September 14, 2020

Job Description:

Make an immediate impact. We offer relocation assistance as well as various opportunities for career growth and development.The Kriwacki lab seeks to understand how phase separation drives the condensation of biomolecules to create liquid-like bodies that mediate diverse biological processes. Importantly, aberrant biomolecular condensation is associated with several devastating human diseases, including cancer and neurodegeneration. A new initiative in the laboratory addresses the role of aberrant phase separation by fusion oncoproteins as drivers in cancer (e.g., NUP98 fusions in AML & AEL). We use integrative approaches, involving a combination of cell and molecular biology, biophysical, and live and fixed cell imaging techniques, coupled with genomics and computational methods, to determine how phase separation by NUP98 (and other) fusion oncoproteins contributes to the formation of aberrant transcription centers on chromatin that drive aberrant gene expression, transform hematopoietic cells and drive oncogenesis. We seek an analytical and self-motivated researcher to join the team as a Bioinformatics Research Scientist to participate in experiments to probe the influence of fusion oncoproteins on chromatin structure, dynamics and function.


  • Perform analyses of large genomics dataset that report on fusion oncoprotein binding to chromatin (e.g., ChIP-seq), and their effects on gene expression (e.g., RNA-seq), chromatin accessibility (e.g., ATAC-seq) and chromatin structure (e.g., HiC and Capture-C).
  • Perform integrative analyses of these large datasets to evaluate correlations between fusion oncoprotein phase separation and chromatin structure (e.g., epigenetic landscape and 3D structure) and function (e.g., gene expression).
  • Assist others in the laboratory with the design and analysis of large genomics datasets and provide training in these areas.
  • Perform project management for studies involving multiple large-scale genomics datasets for multiple fusion oncoprotein-related projects.
  • Participate in the creation and optimization of bioinformatics pipelines used for the analysis of fusion oncoprotein amino acid sequences to identify folded domains and disordered regions, assess phase separation propensity, and identify and characterize low-complexity regions.
  • Manage databases of fusion oncoprotein DNA and protein sequence, information on associated cancer type and incidence, and information on biological function (e.g., GO terms for the parents of fusion oncoproteins).
  • Properly conducts specific projects, maintains efficient laboratory operations and may assist in training other laboratory personnel.
  • Performs other duties as assigned or directed in order to meet the goals and objectives of the department.


    • Ph.D. in Molecular Biology, Biochemistry, Computer Science, Statistics, Mathematics, Bioinformatics or related field required


      • Ph.D which must include research related to bioinformatics (such as analysis of sequence data, microarrays, SNPs, image data, proteomics data, or biological pathways; development of algorithms, statistical methods, or scientific software); OR If Ph.D with no bioinformatics research, then two (2) years of pre-or postdoctoral experience in Computational Biology or Bioinformatics research is required.
      • Experience with programming languages such as Perl, C, or Java required.

        St. Jude is an Equal Opportunity EmployerNo Search Firms:St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Keywords: St. Jude Children's Research Hospital, Raleigh , Bioinformatics Research Scientist Chromatin Structure, Other , Raleigh, North Carolina

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